![]() Early nutrition and gut microbiome: interrelationship between bacterial metabolism, immune system, brain structure, and neurodevelopment. Effects of the human gut microbiota on cognitive performance, brain structure and function: a narrative review. ![]() Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease. The multiple sclerosis gut microbiota: a systematic review. Microbiota‐gut brain axis involvement in neuropsychiatric disorders. Iannone LF, Preda A, Blottière HM, et al. All 3D neural cultures, besides their limitations, could offer important brain features (green box) allowing more accurate, reliable epilepsy modeling, and analysis outputs This technology uses cytocompatible bioinks and offers different approaches to have controlled deposition of cell‐containing scaffolds (lower blue box). To overcome some limitations that unite hydrogels and organoids (random cell placement, small pore sizes, and necrosis due to lack of oxygen and nutrients), another innovative technique is represented by 3D bioprinting. For this purpose, the choice of the best biomaterial is of fundamental importance (upper blue box), with compositions and pore sizes that can be adapted to the specific need. The most used technique to obtain 3D cultures is encapsulation inside cytocompatible biomaterials or scaffolds mainly composed of hydrogels that mimic the brain extracellular matrix (ECM). ![]() Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.ģD neural cultures suitable for epilepsy modeling, taking advantage of the use of patient's primary cell cultures of iPS‐derived differentiated neural cells. Finally, the implementation of existing epilepsy in vitro systems is discussed, offering a complete overview of the available technological tools which may improve reliability and clinical translation of the results towards the development of innovative therapeutic approaches, taking advantage of complementary technologies.ģD culture epilepsy gut‐brain axis microbiota organ‐on‐a‐chip. Subsequently, the currently available strategies to study epilepsy on animal and in vitro models are described, focusing attention on these latter and the technological challenges for integration with already existing MGB axis models. This review summarizes, first of all, the evidence of a role of the MGB axis in epilepsy by providing an overview of the recent clinical and preclinical studies and showing how dietary modification, microbiome supplementations, and hence, microbiota alterations may have an impact on seizures. To dissect the microbiota-gut-brain (MGB) axis involvement in epilepsy, in vitro modeling approaches arouse interest among researchers in the field. Among the recognized causes, a role played by the gut microbiota in epilepsy has been hypothesized and supported by new investigative approaches. To apply for this position, or for any additional information, email to deadline for applications is March 10th.Epilepsy is a common neurological disease characterized by the enduring predisposition of the brain to generate seizures. No tenure-track academic position is linked to this job offer. near the city and the sea, 2 km far from Magna Graecia University and Mater Domini Hospital. We offer flexible working time and a combination of local/remote working schemes. Via Ravenna 7 Localit Difesa, 88050, Catanzaro Italy. Payscale at postdoc level depending on the candidate’s experience. Proved publication track record (minimum Scopus H-index equal to 7).PhD in Biomedical Engineering, Computer Science, Computer Vision, Data Science, Medical Physics, or related field, with emphasis on medical image analysis and artificial intelligence (both machine learning and deep learning).The project, in collaboration with the European Institute of Oncology (Milan) and Azienda Ospedaliero-Universitaria Cagliari, aims at using CT scans and artificial intelligence to predict the therapeutic outcomes (both pharmacological and surgical) for gynecological cancer patients. We are looking for a motivated person to work as a post-doc on a medical image analysis project at Magna Graecia University of Catanzaro, Italy.
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